Abstract: Thin and medium-thickness coal seams are developed commonly in Guizhou, the geologic conditions of coalbed methane ( CBM) exploration are complicated and special.Based on the analysis on the characteristics of coal seams devel-opment in Guizhou, the technology of full-zone and multi-stage fracturing was suggested.Several fractured segments are op-timized in one same well, each segment comprises a plurality of adjacent coal seams and interlays between coal seams. Construction difficulty can be reduced by ball plugging and sand filling&sealing.Full-zone and multi-stage fracturing tech-nology has been applied in CMB ground development demonstration project of Songhe mine of Liupanshui coalfield with some success.