Abstract: In order to probe the genesis and magmatic evolution sequence of the granites in the Harizha sliver polymetallic deposit, geochronological and geochemical studies of the Harizha granodiorite was carried out in this paper. The results show that the Harizha granodiorite has LA-ICP-MS zircon U-Pb age of 423.8±4.3 Ma, indicating that it was formed in late Silurian epoch. It has high contents of SiO₂(71.21%~74.46%), Al₂O₃ (13.48%~14.46%), with K₂O/Na₂O ratios ranging from 1.32 to 1.54, and A/CNK values varying from 1.02 to 1.08, respectively. Thus, the Harizha granodiorite belongs to the high K calc-alkaline weak peraluminous granite. The granodiorite has right declined REE distribution patterns, with strong enrichment of LREE and relative depletion of HREE. It is enriched in Rb, Th, K, depleted in Ba and Nb, Ta, Ti, and has characteristics of the I to S transitional granite. It could be mainly sourced from the partial melting of upper crust gabbros, which is the product of regional post-collision extensional tectonic background.