Abstract: The in-situ U-Pb dating of uranium-rich minerals has extensive applications in geoscience and integrated geological surveys of natural resources. To comprehensively review its research progress and explore the research hotspots and development trends, this study utilized CiteSpace to conduct a visualization analysis of 20,469 related articles from the Web of Science Core Collection (WOS) and the VIP Database from 1991 to 2024, generating relevant knowledge graphs. The results indicate that the development of in-situ U-Pb dating can be broadly divided into three stages: the initial stage (1991—2001), the rapid development stage (2002—2018), and the stable development stage (2019—present). This progress has primarily been driven by advancements in three key areas: analytical instruments, the expansion of dating minerals, and data processing software. Based on the above visualization analysis, this paper summarizes the research progress in in-situ U-Pb dating methods and their applications. It highlights that the current research frontier focuses on the method development and application expansion of U-Pb dating utilization for various minerals. The future research directions include the following: (1) Applying femtosecond laser and reducing the primary ion beam size to enhance the sensitivity, accuracy and spatial resolution of instruments; (2) Developing efficient U-Pb pre-scanning techniques and further investigating the occurrence states of U and Pb in minerals to improve in-situ dating methods of low U minerals; (3) Developing reference materials with diverse compositions and ages, or establishing non-matrix-matched methods to address the scarcity of reference materials for certain dating minerals; (4) Establishing in-situ U-Pb dating methods for new minerals, especially those in sedimentary rocks and ore deposits, and expanding their application fields further; (5) Building AI-based intelligent data processing software to eliminate subjective influences in data processing.