Abstract: On the basis of systematically collecting and sorting the data of predecessors' achievements, and combination of basic geology and remote sensing interpretation, we comprehensively analyzed and sorted out the main active faults and their activity in Pan-Yangtze River Delta region. According to the main regional faults and the activity of historical earthquakes, this paper further analyzed, and pointed out the potential focal region that needs special attention and region of relatively poor crustal stability in this area. The research results show that, there are 38 active faults with relatively strong activity, mainly being in the directions of northeast and northwest. The former mainly on right lateral strike slip activity, the later mainly on left lateral strike slip activity. Then east-west faults with poor activity followed. Furthermore, combining the information of historical earthquake activity, we find that the convergence position of the two groups of fault zone with different directions are often the sites of earthquake occurrence. The most prominent controlled earthquake faults are northeast-orientational Tanlu fault and northwest-orientational Wuxi-Suqian fault.