Abstract: Concerning on the future seismic risk brought by Himalaya orogenic belt after the April 25th, 2015 M8.1 Nepal earthquake, we analyze the strain energy release of Himalaya belt historical great earthquakes and study the regional seismicity images of both pre and post Nepal earthquake. The results show that Himalaya belt may has entered a new round of seismic active period. Crustal strain energy in the middle section of Himalaya belt didn't release completely in this earthquake, the earthquake activity is closely associated between the middle section of Himalaya belt and South Xizang Rift zone, there will be great earthquakes occurring in these two places. Assam gap zone and Bhutan gap zone exist on the east segment of Himalaya belt, meanwhile, Gar gap zone exists on the west, the border region of New Delhi and Xizang in western Himalaya belt and the Gar county area on the Karakorum fault have high seismic risk, Assam and Bhutan in southern Nyingchi, Shannan in eastern Himalaya belt also have high seismic risk, so these zones should be paid more attention to.