Abstract: Mineral resources are essential to human survival and development. So far, 173 minerals have been discovered by Chinese scientists. During this period, a large number of geological data and scientific research achievements have been formed. In this paper, the theoretical and methodological of metallogenic series and integrated geological based on the National Potential Evaluation project were summarized and formed, which is based on the theory of metallogenic series, metallogenic analysis and comprehensive information mineral prediction. The main contents were created the regional comprehensive information mapping, the comprehensive information prediction model and the quantitative prediction of mineral resources. The main method process is to construct the geological spatial database, delineate the types and work areas of mine prediction, compile the thematic prediction base map and comprehensive information prediction element map, construct the comprehensive information prediction model, and carry out the positioning and quantitative prediction of mineral resources.Finally, a case of gold deposit metallogenic prediction in the Xiong’ershan area provides a reference for mineral resources prediction.