| Citation: |
Yi Huang, Xuan Dong, Zhi-yuan Ma, Xi-zhao Tian, Zhu Rao, 2025. Characteristics and ecological risk assessment of antibiotics and hormones in landfill waters, China Geology, 8, 598-606. doi: 10.31035/cg20250076
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Characteristics and ecological risk assessment of antibiotics and hormones in landfill waters
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Abstract
Antibiotics, as emerging pollutants, pose significant risks to aquatic ecosystems and human health by disrupting the endocrine systems of aquatic organisms and affecting ecosystem stability through food chain enrichment. In a study conducted in Hebei Province, China, liquid chromatography-triple quadrupole-linear ion trap mass spectrometry (LC-TQ-LIT-MS) was used to analyze 90 different antibiotics in 31 water samples, including surface water, groundwater, and waste leachate from three urban landfills. This analysis included hormones, broad-spectrum antimicrobials, macrolides, tetracyclines, β-lactams, sulfonamides, and quinolones. The study’s results indicated that quinolones, β-lactams, and macrolides were the most frequently detected substances in the landfills. It is noteworthy that the concentrations of these antibiotics varied significantly among different cities, reflecting local production and living characteristics. The results of the tests showed that the concentration of amoxicillin was 1171 ng/L in surface water, 811 ng/L in groundwater, and 1926 ng/L of ciprofloxacin in waste leachate. Furthermore, a consistent pattern was observed between the compounds present in the leachate, groundwater, and surface water at the three sites. Risk assessments revealed that the ecological risk was higher for surface water and lower for groundwater.
This study is the first to systematically analyze the pollution status of antibiotics and hormones in the water around the landfill in Hebei Province, which not only fills the blank of groundwater-related research in Hebei Province but also provides key data support and theoretical basis for local groundwater hydrological and environmental detection and pollution prevention.
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References
Abd El-Salam MM, Abu-Zuid GI. 2015. Impact of landfill leachate on the groundwater quality: A case study in Egypt. Journal of Advanced Research, 6(4), 579–586. doi: 10.1016/j.jare.2014.02.003. Abdel-Shafy HI, Ibrahim AM, Al-Sulaiman AM, Okasha RA. 2024. Landfill leachate: Sources, nature, organic composition, and treatment: An environmental overview. Ain Shams Engineering Journal, 15(1), 102293. doi: 10.1016/j.asej.2023.102293. Abiriga D, Vestgarden LS, Klempe H. 2020. Groundwater contamination from a municipal landfill: Effect of age, landfill closure, and season on groundwater chemistry. Science of the Total Environment, 737, 140307. doi: 10.1016/j.scitotenv.2020.140307. Chen YL, Jiang CX, Wang YL, Song RR, Tan Y, Yang YY, Zhang ZL. 2022. Sources, environmental fate, and ecological risks of antibiotics in sediments of Asia’s longest river: A whole-basin investigation. Environmental Science & Technology, 56(20), 14439–14451. doi: 10.1021/acs.est.2c03413. Cheng DL, Ngo HH, Guo WS, Chang SW, Nguyen DD, Liu YW, Wei Q, Wei D. 2020. A critical review on antibiotics and hormones in swine wastewater: Water pollution problems and control approaches. Journal of Hazardous Materials, 387, 121682. doi: 10.1016/j.jhazmat.2019.121682. Crystal YO, Luo YL, Duangthip D, El Tantawi M, Benzian H, Schroth RJ, Feldens CA, Virtanen JI, Al-Batayneh OB, Diaz ACM, Vukovic A, Pavlic V, Mfolo T, Daryanavard HA, Gaffar BO, Shamala A, Foláyan MO, Early Childhood Caries Advocacy Group (ECCAG). 2024. A scoping review of the links between early childhood caries and clean water and sanitation: The Sustainable Development Goal 6. BMC Oral Health, 24(1), 769. doi: 10.1186/s12903-024-04535-9. Davies J, Davies D. 2010. Origins and evolution of antibiotic resistance. Microbiology and Molecular Biology Reviews, 74(3), 417–433. doi: 10.1128/MMBR.00016-10. Duong HA, Phung TV, Nguyen TN, Phan Thi LA, Pham HV. 2021. Occurrence, distribution, and ecological risk assessment of antibiotics in selected urban lakes of Hanoi, Vietnam. Journal of Analytical Methods in Chemistry, 2021, 6631797. doi: 10.1155/2021/6631797. Feng L, Cheng YR, Zhang YY, Li ZW, Yu YC, Feng L, Zhang S, Xu LJ. 2020. Distribution and human health risk assessment of antibiotic residues in large-scale drinking water sources in Chongqing area of the Yangtze River. Environmental Research, 185, 109386. doi: 10.1016/j.envres.2020.109386. Frieri M, Kumar K, Boutin A. 2017. Antibiotic resistance. Journal of Infection and Public Health, 10(4), 369–378. doi: 10.1016/j.jiph.2016.08.007. Gaston L, Lapworth DJ, Stuart M, Arnscheidt J. 2019. Prioritization approaches for substances of emerging concern in groundwater: A critical review. Environmental Science & Technology, 53(11), 6107–6122. doi: 10.1021/acs.est.8b04490. Jafari Ozumchelouei E, Hamidian AH, Zhang Y, Yang M. 2020. Physicochemical properties of antibiotics: A review with an emphasis on detection in the aquatic environment. Water Environment Research, 92(2), 177–188. doi: 10.1002/wer.1237. Joakim Larsson DG, Flach CF. 2022. Antibiotic resistance in the environment. Nature Reviews Microbiology, 20(5), 257–269. doi: 10.1038/s41579-021-00649-x. Lee KH, Noh J, Khim JS. 2020. The Blue Economy and the United Nations’ sustainable development goals: Challenges and opportunities. Environment International, 137, 105528. doi: 10.1016/j.envint.2020.105528. Li CQ, Li LX, Ren YJ, Zhao JH, Huang G, Zhou SY, Liu LP, Jiang JS, Liang F. 2024. Determination of 35 antibiotics in surface water by high performance liquid chromatography-tandem mass spectrometry with online solid-phase extraction and large-volume injection. Rock and Mineral Analysis, 43(6), 945–956. doi: 10.15898/j.ykcs.202404050076. Liu K, Gan C, Peng YE, Gan YQ, He J, Du Y, Tong L, Shi JB, Wang YX. 2024. Occurrence and source identification of antibiotics and antibiotic resistance genes in groundwater surrounding urban hospitals. Journal of Hazardous Materials, 465, 133368. doi: 10.1016/j.jhazmat.2023.133368. Ma JW, Cui YB, Li AM, Zhang WJ, Ma CD, Luosang ZM, Chen ZB, Zhao K. 2021. Tracking macrolides, sulfonamides, fluoroquinolones, and tetracyclines in sludge treatment wetlands during loading and resting periods. Separation and Purification Technology, 279, 119599. doi: 10.1016/j.seppur.2021.119599. Niu Y, An S, Chen K, Qin JJ, Liu F. 2023. A review of current status and analysis methods of antibiotic contamination in groundwater in China (2012—2021). Rock and Mineral Analysis, 42(1), 39–58. doi: 10.15898/j.cnki.11-2131/td.202210120192. Pan CY, Bao YY, Xu BT. 2020. Seasonal variation of antibiotics in surface water of Pudong New Area of Shanghai, China and the occurrence in typical wastewater sources. Chemosphere, 239, 124816. doi: 10.1016/j.chemosphere.2019.124816. Parvin F, Tareq SM. 2021. Impact of landfill leachate contamination on surface and groundwater of Bangladesh: A systematic review and possible public health risks assessment. Applied Water Science, 11(6), 100. doi: 10.1007/s13201-021-01431-3. Rouhani A, Bradák B, Makki M, Ashtiani B, Hejcman M. 2022. Ecological risk assessment and human health risk exposure of heavy metal pollution in the soil around an open landfill site in a developing country (Khesht, Iran). Arabian Journal of Geosciences, 15(18), 1523. doi: 10.1007/s12517-022-10792-1. Salma U, Nishimura Y, Tokumura M, Hossain A, Watanabe K, Noro K, Raknuzzaman M, Amagai T, Makino M. 2025. Occurrence, seasonal variation, and environmental risk of multiclass antibiotics in the urban surface water of the Buriganga River, Bangladesh. Chemosphere, 370, 143956. doi: 10.1016/j.chemosphere.2024.143956. Samadder SR, Prabhakar R, Khan D, Kishan D, Chauhan MS. 2017. Analysis of the contaminants released from municipal solid waste landfill site: A case study. Science of the Total Environment, 580, 593–601. doi: 10.1016/j.scitotenv.2016.12.003. Seifrtová M, Nováková L, Lino C, Pena A, Solich P. 2009. An overview of analytical methodologies for the determination of antibiotics in environmental waters. Analytica Chimica Acta, 649(2), 158–179. doi: 10.1016/j.aca.2009.07.031. Tuts L, Rasschaert G, Heyndrickx M, Boon N, Eppinger R, Becue I. 2024. Detection of antibiotic residues in groundwater with a validated multiresidue UHPLC-MS/MS quantification method. Chemosphere, 352, 141455. doi: 10.1016/j.chemosphere.2024.141455. Wu HX, Liu RJ, Liu GJ, He M, Arif M, Li FM, Si W, Yue Z, Hu H. 2024. Unveiling antibiotic contamination in surface water: A study of the Huaihe River Basin’s Huaibei Plain, a significant Chinese herbal medicine planting region. Science of the Total Environment, 933, 173125. doi: 10.1016/j.scitotenv.2024.173125. Xue XD, Chen BH, Wang H, Fang CR, Long YY, Hu LF. 2021. Antibiotics in the municipal solid waste incineration plant leachate treatment process. Chemistry and Ecology, 37(7), 633–645. doi: 10.1080/02757540.2021.1924695. Ying JL, Qin XP, Lang H, Guo JY, Xiong L, Zhang ZH, Liu F. 2022. Determination of 37 typical antibiotics by liquid chromatography-triple quadrupole mass spectrometry. Rock and Mineral Analysis, 41(3), 394–403. doi: 10.15898/j.cnki.11-2131/td.202111060168. Yu KN, Wang RZ, Liu DD. 2023. A review of rapid detections for emerging contaminants in groundwater. Rock and Mineral Analysis, 42(6), 1063–1077. doi: 10.15898/j.ykcs.202302080018. Yu X, Sui Q, Lyu SG, Zhao WT, Liu JG, Cai ZX, Yu G, Barcelo D. 2020. Municipal solid waste landfills: An underestimated source of pharmaceutical and personal care products in the water environment. Environmental Science & Technology, 54(16), 9757–9768. doi: 10.1021/acs.est.0c00565. Zainab SM, Junaid M, Xu N, Malik RN. 2020. Antibiotics and antibiotic resistant genes (ARGs) in groundwater: A global review on dissemination, sources, interactions, environmental and human health risks. Water Research, 187, 116455. doi: 10.1016/j.watres.2020.116455. Zhang R, Yang S, An YW, Wang YQ, Lei Y, Song LY. 2022. Antibiotics and antibiotic resistance genes in landfills: A review. Science of the Total Environment, 806, 150647. doi: 10.1016/j.scitotenv.2021.150647. Zhou P, Zeng D, Wang XT, Tai LY, Zhou WW, Zhuoma QD, Lin FW. 2022. Pollution levels and risk assessment of heavy metals in the soil of a landfill site: A case study in Lhasa, Tibet. International Journal of Environmental Research and Public Health, 19(17), 10704. doi: 10.3390/ijerph191710704. -
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Yi Huang, Xuan Dong, Zhi-yuan Ma, Xi-zhao Tian, Zhu Rao, 2025. Characteristics and ecological risk assessment of antibiotics and hormones in landfill waters, China Geology, 8, 598-606. doi: 10.31035/cg20250076
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Figure 1.
Map of sampling sites in the three cities.
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Figure 2.
Total ion current diagram (TIC) of 90 antibiotics at 50 ng/L.
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Figure 3.
Comparison of the distribution of antibiotics and hormones in surface water of three cities.
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Figure 4.
Comparison of the distribution of antibiotics and hormones in groundwater of three cities.
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Figure 5.
Risk assessment cluster diagram.